Chloroacetyl chloride → HCID 66915778, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 70 mg 3-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-5,5-dimethyl-1-quinolin-4-ylmethyl-imidazolidine-2,4-dione in 2 ml 1,2-dichloroethane in a process vial 0.06 ml ethyl-diisopropyl-amine and 13.5 mg chloroacetylchloride were added at 0° C. After stirring for 1 hour at 0° C. 33.9 mg 1-methyl-piperazine were added. The resulting mixture was stirred for 2 hours at room temperature. The solvent was removed under reduced pressure and the residue purified by preparative HPLC (C18 reverse phase column, elution with a water/acetonitrile gradient with 0.1% trifluoracetic acid). Lyophilization of the solution yielded a white solid.

Provenance & Evidence