Triethylamine → HCID 178465594, compound

Participants

Reaction Conditions

Reaction Steps

C-(7-Benzenesulfonyl-chroman-4-yl)-methylamine HCl salt (90 mg, 0.26 mmol) and methyl imidate (acetimidic acid methyl ester, 58 mg, 0.529 mmol) were dissolved in 3 mL of absolute ethanol and 0.362 mL of triethylamine (2.6 mmol) was added. The reaction mixture was stirred at 80° C. for 2 days. It was then cooled, partitioned between EtOAc and water, dried over MgSO4 concentrated and purified using column chromatography (silica gel, MeOH/CHCl3/NH4OH 10:89:1) After formation of the HCl salt, 9 mg (10%) of. N-(7-Benzenesulfonyl-chroman-4-ylmethyl)-acetamidine was collected. MS: 345 (M+H)+.

Provenance & Evidence