Sodium borohydride → HCID 58668696, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-(3-Fluoro-benzenesulfonyl)-chroman-4-one (3.31 g, 10.81 mmol) in THF (100 ml) was added NaBH4 (0.49 g, 12.9 mmol) at 0° C. The mixture was stirred at 0° C. for 3 hours. The reaction mixture was partitioned between water and EtOAc. The EtOAc layer was washed with brine, dried with MgSO4, filtered and concentrated. The residue was purified with flash chromatography to give 2.0 g of 7-(3-Fluorobenzene-sulfonyl)-chroman-4-ol, as a white foam. MS: 599.2 (2M−OH)+.

Provenance & Evidence