Dimethyl Sulfide → HCID 68459038, compound

Participants

Reaction Steps

To a solution of [7-(3-Fluoro-benzenesulfonyl)-chroman-4-yl]-acetic acid (1.5 g, 4.28 mmol) in THF 40 ml) was added BH3 Me2S (0.41 ml, 4.32 mmol) at 0° C. The mixture was stirred in the ice bath for 30 minutes and then at room temperature overnight. The mixture was quenched with MeOH and the solvent was removed. The residue was dissolved in EtOAc, washed with brine, dried with MgSO4, filtered and concentrated to give 2-[7-(3-Fluoro-benzenesulfonyl)-chroman-4-yl]-ethanol as a clear syrup: 1.35 g; MS: 337.2 (M+H)+, 378.2(M+CH3CN+H)+.

Provenance & Evidence