Boron tribromide → HCID 178524540, compound

HRID 2356997Notes

Reaction equation

HRID 2356997 reaction equation
C[O:2][C:3](=[O:17])[C:4]1[C:9]([Cl:10])=[CH:8][C:7]([C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[CH:6][C:5]=1[Cl:16].B(Br)(Br)Br>ClCCl>[Cl:16][C:5]1[CH:6]=[C:7]([C:11]2[NH:15][N:14]=[N:13][N:12]=2)[CH:8]=[C:9]([Cl:10])[C:4]=1[C:3]([OH:17])=[O:2]

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 178498353HCID 178498353, compound

Product 1

HCID 178524540HCID 178524540, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent3×

Procedure

The mixture of 110 mg of 2,6-dichloro-4-tetrazolylbenzoic acid methylester, 0.5 ml of dichloromethane solution containing 1M BBr3 and 5 ml of dichloromethane was stirred overnight. The obtained substance was treated by an ordinary method using dichloromethane as an extractant and purified by reverse phase HPLC to obtain the title compound.

Workup

  1. additionThe obtained substance was treated by an ordinary method
  2. custompurified by reverse phase HPLC

Sources & evidence

ORD record
ord-7f6e290710c34046a5d620053fc92c10
Source dataset
uspto-grants-2010_07
Patent number
US07759388B2

Reaction notes

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