Methylhydrazine → 1-Methyl-4-phenyl-1H-pyrazole

HRID 2357008Notes

Reaction equation

HRID 2357008 reaction equation
[C:1]1([CH:7]([CH:10]=O)[CH:8]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][NH:13][NH2:14]>C(O)C>[CH3:12][N:13]1[CH:10]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:8]=[N:14]1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 36722962-phenylmalonaldehyde

Product 1

HCID 136924421-Methyl-4-phenyl-1H-pyrazoleYield 102.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g of 2-phenylmalonaldehyde (6.75 mmol) were dissolved in 25 ml of ethanol. 0.36 ml of N-methyl-hydrazine (6.75 mmol) were added, the reaction mixture was stirred under reflux for 4 h, the solvent evaporated under reduced pressure to yield 1.09 g of the product.

Workup

  1. temperatureunder reflux for 4 h
  2. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-74d6351c4d9241ad9d737c39912019f0
Source dataset
uspto-grants-2010_07
Patent number
US07759397B2

Reaction notes

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