Acetic Acid → HCID 145723584, compound

HRID 2357028Notes

Reaction equation

HRID 2357028 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:38])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:37])[CH2:16][N:17]2[CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:26]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[NH:27])[CH:23]=3)[C:18]2=[O:36])=[CH:11][CH:10]=1)C.CC(O)=O>CO>[C:32]([O:31][C:29]([NH:28][C:26](=[NH:27])[C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][CH:21]=1)[C:18](=[O:36])[N:17]([CH2:16][C:15]([C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:7][C:6]([OH:38])=[O:5])=[CH:14][CH:13]=1)=[O:37])[CH2:25]2)=[O:30])([CH3:35])([CH3:33])[CH3:34]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 145723586HCID 145723586, compound

Product 1

HCID 145723584HCID 145723584, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aqueous 0.1N NaOH (11.4 ml; 1.14 mmol) was added to a solution of the compound of example 17a (0.375 g; 0.756 mmol) in MeOH (10 ml), The reaction mixture was stirred at room temperature for 30 min., acidified with AcOH and concentrated. The crude title compound obtained was filtered, washed with cold water and dried under vacuum. Yield, 140 mg.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-566adbc7ff684e81bc679f899296d7f4
Source dataset
uspto-grants-2010_07
Patent number
US07759387B2

Reaction notes

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