2',4'-Dihydroxyacetophenone → HCID 67245703, compound

Participants

Reaction Steps

1-(2,4-Dihydroxy-phenyl)-ethanone was treated with 1 equivalent of benzyl 2-bromoacetate and processed as described in the synthesis of example 20a to obtain the title compound. The crude was purified using flash chromatography (silica gel, 3% CH3CN in chloroform) and crystallization was effected using ether-PE 60-80° C. Yield, 75%, white solid; mp, 66-67° C.; MS (EI): 300 (M+), 285, 165, 91 (100%); analysis: C17H16O5 requires C, 67.99; H, 5.37; found: C, 67.99; H, 5.53%.

Provenance & Evidence