Acetyl chloride → HCID 67247374, compound

Participants

Reaction Steps

The compound of example 65c (38 g; 112.5 mmol) was heated with acetyl chloride (9.74 ml; 137 mmol) and activated Zn (7.46 g) in toluene (250 ml) for 5 h (Synth. Commun. 1998, 28, 2203). to obtain the title compound which was processed as is routinely done and purified using flash chromatography (silica gel, 3% CH3CN in chloroform). Yield, 30 g (78.3%); MS (CI): 409 (M++29), 381(M+); analysis: C16H20O8 requires C, 56.47; H, 5.92; found: C, 56.05; H, 5.59%.

Provenance & Evidence