Acetic Anhydride → HCID 67246034, compound

HRID 2357050Notes

Reaction equation

HRID 2357050 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH2:5][N:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:15](=[NH:18])[NH:16][OH:17])[CH:12]=2)[C:7]1=[O:19])[CH3:2].[C:21](OC(=O)C)(=O)[CH3:22]>>[CH2:1]([O:3][C:4](=[O:20])[CH2:5][N:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:15]3[N:18]=[C:21]([CH3:22])[O:17][N:16]=3)[CH:12]=2)[C:7]1=[O:19])[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178472590HCID 178472590, compound

Product 1

HCID 67246034HCID 67246034, compound

Procedure

The compound of example 66b (1 g; 3.8 mmol) in acetic anhydride (20 ml) was heated at 120° C. for 4 h. It was concentrated and purified using flash chromatography (silica gel, 5% CH3CN in dichloromethane) to obtain the title compound. Yield, 0.6 g (55%); mp, 155° C.; MS (ESI−): 286 (M−1), analysis: C14H13N3O4 requires C, 58.53; H, 4.56; N, 14.63; found: C, 58.13; H, 4.79; N, 14.14%.

Workup

  1. concentrationIt was concentrated
  2. custompurified

Sources & evidence

ORD record
ord-41a0b21e95894efdbdb233049cce4cd0
Source dataset
uspto-grants-2010_07
Patent number
US07759387B2

Reaction notes

Loading…