HCID 131728250, compound → HCID 131728249, compound

Participants

Reaction Conditions

Reaction Steps

11.0 g (15 mmol) N-[3-(1-{5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-nitro-1H-indol-3-yl)-prop-2-ynyl]-2,2,2-trifluoro-acetamide were dissolved in 260 ml 7N ammonia solution in methanol (Aldrich, 499145). The solution was maintained at 8° C. for 16 h. The solvent was removed in a vacuum on a rotary evaporator (water bath 38° C.). The residue was chromatographed on a silica gel column (Silica gel 60, Merck, 280×85 mm) with a solvent mixture of ethyl acetate:methanol:toluene 1:1:4 (v/v/v) with 0.2 vol % triethylamine (yield: 6.1 g).

Provenance & Evidence