HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59384375, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Diethyl chlorophosphate | HCID 13139 | — |
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | HCID 25060423 | HCID 25060423 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59384375 | HCID 59384375 | — |
Reaction Steps
E1 (25 mg, 1.0 equiv), DCM (5 mL), diethyl chlorophosphate (85 μL, 10.0 equiv) and triethylamine (165 μL, 20.0 equiv) were stirred overnight. The obtained phospho-diester intermediate was reacted with excess bromotrimethylsilane in DCM for 5 hrs. The resulting phosphate was purified by preparative HPLC as the trifluoroacetate salt (10 mg). MS (ESI, M+H+)=511.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759370B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-cf5d552473344cb7bed4076a30c57554 |
| Source note | uspto-grants-2010_07 |