HCID 22505858, compound → HCID 58947886, compound

Participants

Reaction Steps

4.0 g (9.3 mmol) 2,2,2-Trifluoro-N-{3-[1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-nitro-1H-indol-3-yl]-prop-2-ynyl}-acetamide and 650 mg 5% (w/w) palladium on charcoal (Fluka No: 75992) were suspended in 100 ml anhydrous ethanol and placed under argon atmosphere in a flask. The argon was substituted by hydrogen (Whatman hydrogen generator). The hydrogenation was monitored by TLC (Silica Gel Merck F60, developing solvent: toluene/acetic acid ethyl ester/methanol 4:1:1 (v/v/v)) and stopped when the starting material was no longer detectable. The catalyst was removed by filtration and the solvent evaporated to dryness in a vacuum on a rotary evaporator. The product was used without further purification (yield: 3.7 g).

Provenance & Evidence