Butyryl chloride → HCID 67105835, compound

Participants

Reaction Steps

4-(6-hydroxy-indan-1-ylmethyl)-1H-imidazol-1-ium chloride (100 mg, 0.399 mmol) and butyric acid chloride (510 mmol) were reacted in TFA (1 ml) and purified as described in example 1. Yield 90 mg (77%) of a white hygroscopic solid. 1H NMR (CDCl3, TMS): δ 1.02 (t, 3H), 1.70-1.79 (m, 3H), 2.18-2.24 (m, 1H), 2.52 (t, 2H), 2.73-2.86 (m, 3H), 3.18 (dd, 1H), 3.53 (qui, 1H), 6.84 (dd, 1H), 6.87 (s, 1H), 6.92 (s, 1H), 8.66 (s, 1H), 11.28 (s (broad), 2H). 13C NMR (CDCl3, TMS): δ 13.66, 18.45, 29.68, 30.52, 31.68, 36.24, 43.98, 115.79, 117.05, 120.36, 125.36, 132.32, 132.59, 141.32, 146.36, 149.51, 172.85.-HPLC-MS (EI): m/z=285.2 ((M+H)+—Cl−). Anal.—Calc. for C17H20N2O2.HCl.0.2CH2Cl2: C, 61.16; H, 6.39; N, 8.29. Found C, 61.30; H, 6.46; N, 8.22.

Provenance & Evidence