Cyclopropylamine → HCID 9813573, compound

HRID 2357203Notes

Reaction equation

HRID 2357203 reaction equation
Cl[C:2]1[C:7]([CH:8]=[O:9])=[C:6]([Cl:10])[N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[CH:13]1([NH2:16])[CH2:15][CH2:14]1>>[Cl:10][C:6]1[C:7]([CH:8]=[O:9])=[C:2]([NH:16][CH:13]2[CH2:15][CH2:14]2)[N:3]=[C:4]([S:11][CH3:12])[N:5]=1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 46140044,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

Product 1

HCID 9813573HCID 9813573, compound

Procedure

Prepared as described above in Example 2 starting from 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde and cyclopropylamine to give the title compound 4-chloro-6-cyclopropylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ 0.68 (m, 2H), 0.90 (m, 2H), 2.58 (s, 3H), 3.07 (m, 1H), 9.20 (br s, 1H), 10.28 (s, 1H). LC MS (m/e)=244 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8ab8af726d2441f0b3def3320347c106
Source dataset
uspto-grants-2010_07
Patent number
US07759486B2

Reaction notes

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