Serinol → HCID 10134609, compound

HRID 2357231Notes

Reaction equation

HRID 2357231 reaction equation
[CH:1]1([N:4]2[C:9]3[N:10]=[C:11](S(C)(=O)=O)[N:12]=[C:13]([C:14]4[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=4[CH3:21])[C:8]=3[CH:7]=[CH:6][C:5]2=[O:26])[CH2:3][CH2:2]1.[NH2:27][CH:28]([CH2:31][OH:32])[CH2:29][OH:30]>>[CH:1]1([N:4]2[C:9]3[N:10]=[C:11]([NH:27][CH:28]([CH2:31][OH:32])[CH2:29][OH:30])[N:12]=[C:13]([C:14]4[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=4[CH3:21])[C:8]=3[CH:7]=[CH:6][C:5]2=[O:26])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 68294SerinolHCID 10133919HCID 10133919, compound

Product 1

HCID 10134609HCID 10134609, compound

Procedure

The product of Example 54, and serinol were reacted by the procedure of Example 60 to afford the title compound 8-cyclopropyl-4-(4-fluoro-2-methyl-phenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one. 1H-NMR: δ 0.85 (m, 2H), 1.28 (m, 2H), 2.11 (m, 3H), 2.79 (m, 1H), 3.89 (m, 4H), 4.16 (m, 1H), 6.18 (d, 1H, J=9.8), 6.31 (br s, 1H), 6.85-7.14 (m, 4H). LC MS (m/e)=385 (MH+).

Sources & evidence

ORD record
ord-8e31d2d770854600baa5abf33d89220d
Source dataset
uspto-grants-2010_07
Patent number
US07759486B2

Reaction notes

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