N,N-Diethylethylenediamine → HCID 10114239, compound

HRID 2357245Notes

Reaction equation

HRID 2357245 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]2[CH:19]=[CH:18][C:17](=[O:20])[N:16]([CH:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[C:10]=2[N:11]=[C:12](SC)[N:13]=1.[CH2:26]([N:28]([CH2:32][CH3:33])[CH2:29][CH2:30][NH2:31])[CH3:27]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]2[CH:19]=[CH:18][C:17](=[O:20])[N:16]([CH:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[C:10]=2[N:11]=[C:12]([NH:31][CH2:30][CH2:29][N:28]([CH2:32][CH3:33])[CH2:26][CH3:27])[N:13]=1

Participants

3

Reactant 2

HCID 60993N,N-DiethylethylenediamineHCID 10109920HCID 10109920, compound

Product 1

HCID 10114239HCID 10114239, compoundYield 80%

Procedure

The product of Example 44, and N,N-diethylethylenediamine were reacted by the procedure of Example 60 to afford 4-(2-chloro-phenyl)-2-(2-diethylamino-ethylamino)-8-(1-ethyl-propyl)-8H-pyrido[2,3-d]pyrimidin-7-one (371 mg, 80% yield. LC MS (m/e)=442 (MH+). Rt=1.77 min.

Sources & evidence

ORD record
ord-8b79225051f742efab61bb96179c3973
Source dataset
uspto-grants-2010_07
Patent number
US07759486B2

Reaction notes

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