Acetic Anhydride → HCID 59639614, compound

Participants

Reaction Conditions

Reaction Steps

The product of Example 131 (61 mg, 0.14 mmol) was dissolved in CH2Cl2 (2 mL) and stirred at 0° C. under Ar. Triethylamine (0.1 mL) was added followed by the addition of acetic anhydride (0.2 g, 2 mmol). The reaction was allowed to slowly warm to 230 and stir for 18 h. The solvents were removed in vacuo, and the residue was flash chromatographed eluted with 10-30% EtOAc/CH2Cl2 to give the title compound as a white-amorphous solid. mp 75-79°, LC MS m/z=469 (MH+). Retention time=1.95 min.

Provenance & Evidence