HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → HCID 59639632, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 8-(2,6-difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one | HCID 59639554 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59639632 | HCID 59639632 | — |
Reaction Steps
The product of Example 48 (200 mg, 0.45 mmol) and cyclohexylamine (100 mg, 1 mmol) were combined in THF (10 mL) and stirred under Ar at 230 for 18 h. The solvents were removed in vacuo, and the residue was flash chromatographed with 50-100% CH2Cl2/hexane. Recrystallization from CH2Cl2/hexane gave the title compound as a white-crystalline solid. mp 218-219° C., LC MS m/z=465 (MH+). Retention time=2.8 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759486B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-6c73dfcb31c741678f302e2d0c1a26a1 |
| Source note | uspto-grants-2010_07 |