HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 2733686, compound → HCID 66894359, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 2733686 | HCID 2733686 | — |
| Reactant | 8-(2,6-difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one | HCID 59639554 | — |
| Product | HCID 66894359 | HCID 66894359 | — |
Reaction Steps
Following the general procedure outlined in Example 225, the product of Example 48 (150 mg, 0.34 mmol) and cis-2-amino-1-cyclopentanecarboxamide (139 mg, 1.02 mmol) were reacted to give the crude material. Purification by flash chromatography eluting with EtOAc/hexane/triethylamine (50/50/2, v/v/v), followed by recrystallization from dichloromethane and hexane, afforded the desired product, 87 mg (52%). LC-MS: 494.0 (MH+, m/z), 2.00 (Rt, min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759486B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-b90d167f33f54c92ba877caad5737909 |
| Source note | uspto-grants-2010_07 |