2-Methylimidazole → HCID 68454783, compound

Participants

Reaction Steps

A mixture of α-(4′-chlorophenyl)-4-acetyloxy-3-methoxy cinnamic acid (0.0083 mol), NaHCO3 (10%, 5 mL) and methylimidazole (2 mL) and diethylene glycol (8 mL) were taken in a 100 ml round bottom flask fitted with a condenser. The flask was shaken well and placed inside the microwave oven and irradiated (200 W, 180° C.) for 9 minutes in parts. After completion of reaction, the reaction mixture was worked (yield 89%) as in example I; solid, (m.p. 121-124° C.); 1H NMR (CDCl3) δ 7.35 (2H, d, J=8.48 Hz), 7.25 (2H, d, J=8.07 Hz), 6.96 (3H, m), 6.87 (2H, d, J=8.07 Hz), 5.72 (1H, s), 3.87 (3H, s); 13C NMR (CDCl3) δ 146.8, 145.8, 136.1, 132.7, 129.6, 129.2, 128.8, 127.4, 125.1, 120.6, 114.6, 108.3 and 55.9. HREIMS data: m/z [M+H]+ for C15H14O2Cl, calculated=261.7229; observed=261.7228.

Provenance & Evidence