Acetic Acid → {4-[3-(1H-indol-3-yl)-pyrrolidine-1-yl]-1-phenyl-cyclohexyl}-dimethylamine

HRID 2357430Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2357430
[CH3:1][N:2]([CH3:16])[C:3]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.[NH:17]1[CH2:21][CH2:20][CH:19]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[NH:24][CH:23]=2)[CH2:18]1.C(O)(=O)C.S([O-])([O-])(=O)=O.[Na+].[Na+]>ClCCCl.O1CCCC1>[NH:24]1[C:25]2[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]([CH:19]2[CH2:20][CH2:21][N:17]([CH:6]3[CH2:7][CH2:8][C:3]([N:2]([CH3:16])[CH3:1])([C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)[CH2:4][CH2:5]3)[CH2:18]2)=[CH:23]1

Komponenten

7

Edukt 4

HCID 176Acetic AcidHCID 24436Sodium SulfateHCID 114244924-(Dimethylamino)-4-phenylcyclohexan-1-oneHCID 184096763-(pyrrolidin-3-yl)-1H-indole

Produkt 1

HCID 11753987{4-[3-(1H-indol-3-yl)-pyrrolidine-1-yl]-1-phenyl-cyclohexyl}-dimethylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 111,2-DichloroethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

4-dimethylamino-4-phenylcyclohexanone (217 mg, 1 mmole) and 3-pyrrolidine-3-yl-1H-indole (186 mg, 1 mmole) were dissolved in a mixture of dry 1,2-dichloroethane (5 ml) and tetrahydrofuran (15 ml). Glacial acetic acid (57 μl, 1 mmole) and sodium sulfate (500 mg) were added to this mixture. After a reaction time of 15 minutes sodium triacetoxy boron hydride (318 mg, 1.5 mmole) was added to the reaction mixture and stirred for 4 days at RT. The reaction mixture was worked up by distilling off the solvent and adding saturated sodium hydrogen carbonate solution (20 ml) and water (20 ml). This aqueous phase was extracted with DCM (3×30 ml). The organic phase was dried with Na2SO4 and concentrated by evaporation. The chromatographic purification of the substance mixture was carried out on silica gel with methanol/30% aqueous ammonia (500:1). On dissolving the substance mixture in the solvent a colourless solid precipitated out, which was filtered off. This was identified by NMR spectroscopy as the non-polar diastereoisomer of {4-[3-(1H-indol-3-yl)-pyrrolidine-1-yl]-1-phenylcyclohexyl}-dimethylamine. The non-polar diastereoisomer was obtained in a yield of 79 mg (20%). The remaining substance mixture was purified by flash chromatography. The diastereoisomer mixture was obtained in a yield of 136 mg (35%).

Aufarbeitung

  1. distillationby distilling off the solvent
  2. additionadding saturated sodium hydrogen carbonate solution (20 ml) and water (20 ml)
  3. extractionThis aqueous phase was extracted with DCM (3×30 ml)
  4. dry with materialThe organic phase was dried with Na2SO4
  5. concentrationconcentrated by evaporation
  6. customThe chromatographic purification of the substance mixture
  7. dissolutionOn dissolving the substance mixture in the solvent a colourless solid
  8. customprecipitated out
  9. filtrationwhich was filtered off
  10. customThe non-polar diastereoisomer was obtained in a yield of 79 mg (20%)
  11. customThe remaining substance mixture was purified by flash chromatography
  12. customThe diastereoisomer mixture was obtained in a yield of 136 mg (35%)

Quellen und Nachweise

ORD-Eintrag
ord-98bf447598f54fe4aaef82df6107d71f
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07759385B2

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