3-(1-benzyl-1,2,5,6-tetrahydropyridine-3-yl)-1H-indole → 3-(Piperidin-3-YL)-1H-indole

Participants

Reaction Steps

3-(1-benzyl-1,2,5,6-tetrahydropyridine-3-yl)-1H-indole (430 mg, 1.48 mmole) was dissolved in methanol (30 ml) under argon. Pd/carbon (43 mg, 10%) was added and the reaction mixture was hydrogenated for 16 hours at 2 bar. The reaction mixture was worked up by filtering the solution through silica gel and washing with methanol (10×10 ml). The filtrate was concentrated by evaporation and dried. 3-piperidine-3-yl-1H-indole was obtained as a yellow oil in a yield of 233 g (79%).

Provenance & Evidence