Chlorotrimethylsilane → {4-[3-(1H-indol-3-yl)piperidine-1-yl]-1-phenylcyclohexyl}-dimethylamine dihydrochloride

Participants

Reaction Steps

To prepare the dihydrochloride the non-polar diastereoisomer of {4-[3-(1H-indol-3-yl)piperidine-1-yl]-1-phenylcyclohexyl}-dimethylamine (208 mg, 0.52 mmole) was dissolved in ethyl methyl ketone (5 ml) and chlorotrimethylsilane (165 μl, 1.3 mmole) was added. The solid thereby obtained was filtered off and dried. The non-polar {4-[3-(1H-indol-3-yl)piperidine-1-yl]-1-phenylcyclohexyl}-dimethylamine dihydrochloride was thereby obtained as a colourless solid with an m.p. of 188°-190° C. in a yield of 245 mg (100%) (Example 9).

Provenance & Evidence