Hydrochloric Acid → 3-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylic acid-(4-dimethylamino-4-phenylcyclohexyl)-amide

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Reaction Steps

To prepare the hydrochloride the non-polar diastereoisomer of 3-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylic acid-(4-dimethylamino-4-phenylcyclohexyl)-amide (217 mg, 0.45 mmole) was dissolved in ethyl methyl ketone (5 ml) and chlorotrimethylsilane (86 μl, 0.68 mmole) was added. The solid thereby formed was filtered off and dried. The hydrochloride of the non-polar diastereoisomer of 3-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylic acid-(4-dimethylamino-4-phenylcyclohexyl)-amide was thereby obtained in a yield of 233 mg (100%) as a colourless solid (Example 35) with an m.p. of 195°-198° C.

Provenance & Evidence