Chlorotrimethylsilane → 2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)piperidine-1-yl]-ethanone hydrochloride

Participants

Reaction Steps

2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)piperidine-1-yl]-ethanone (66 mg, 0.148 mmole) was dissolved in ethyl methyl ketone (4 ml) and chlorotrimethylsilane (0.03 ml, 0.23 mmole) was added. After 1 hour the hydrochloride was isolated as a colourless solid in a yield of 65% (46 mg) (Example 53). A melting point could not be determined. The hydrochloride was obtained as a diastereoisomer mixture.

Provenance & Evidence