Chlorotrimethylsilane → 2-(4-dimethylamino-4-(4-fluorophenyl)cyclohexylidene)-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone hydrochloride

Participants

Reaction Steps

Chlorotrimethylsilane (0.13 ml, 1.01 mmole) was added to a solution of 2-(4-dimethylamino-4-(4-fluorophenyl)-cyclohexylidene)-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]ethanone (300 mg, 0.67 mmole) in ethyl methyl ketone (25 ml) and stirred for 2 hours at RT. The hydrochloride (300 mg, 93%) thereupon precipitated as a diastereoisomer mixture with a melting point of 189°-194° C. in the form of a colourless solid (Example 60).

Provenance & Evidence