Hydrazine hydrate (1:1) → HCID 178518884, compound

Participants

Reaction Steps

A mixture of 5-bromo-3-hydroxyisoindolin-1-one (16, 17.0 g, 75 mmol), and hydrazine, monohydrate (60 mL, 1193 mmol) was stirred at room temperature for 15 h, after which a white solid precipitated out (M+1=225, 227). The mixture was diluted with 100 mL H2O, neutralized with conc. HCl to a PH of about 7. The precipitate was filtrated and washed with 100 mL H2O. The solid was collected, azeotropically dried with toluene (3×50 mL) and further dried in a vacuum oven at 45° C. for 15 h, to yield 6-bromophthalazin-1-ol 17 (16.1 g). Found MS (ES+): 225, 227 (M+H)+.

Provenance & Evidence