HRID235752

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(C)(C)[C@H]1C(=O)N[C@@H]1CC(=O)C(=[N+]=[N-])C(=O)OCc1ccc([N+](=O)[O-])cc1

HCID86741280

未命名化合物

PRODUCTS

生成物

结构：COC(C)(C)[C@H]1C(=O)N2[C@@H](C(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)C[C@H]12

HCID86741282

未命名化合物

收率 95.1%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID21674

Acetic acid, rhodium(2+) salt

C4H6O4Rh

溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

A mixture of 4-nitrobenzyl 2-diazo-4-[(2R, 3S)-3-(1-methoxy-1-methylethyl)-4-oxo-azetidin-2-yl]-3-oxobutanoate (56.5 mg) and a catalytic amount of rhodium (II) acetate (ca. 1 mg) in dry benzene (5.6 ml) was refluxed for 30 minutes. After cooling to ambient temperature, the mixture was filtered and evaporated in vacuo to give 4-nitrobenzyl (2R, 5R, 6S)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo[3.2.0]-heptane-2-carboxylate (50.0 mg) as an amorphous solid.

WORKUP

后处理

filtrationthe mixture was filtered
customevaporated in vacuo