Dimethyl Sulfate → HCID 86607605, compound

Participants

Reaction Conditions

Reaction Steps

To 2,2,2-trifluoro-N-(7-iodo-6-methylbenzo[d]isoxazol-3-yl)acetamide in acetone (5.0 mL) at RT was added dimethyl sulfate (766 mg, 6.07 mmol) and potassium carbonate (1.40 g, 10.12 mmol). The mixture was heated at 50° C. in an oil bath for 5 h, then cooled to RT, filtered through a pad of Celite and rinsed with additional acetone (2×5 mL). The filtrate was concentrated to dryness to provide 2,2,2-trifluoro-N-(7-iodo-6-methylbenzo[d]isoxazol-3-yl)-N-methylacetamide. MS (ESI, pos. ion) m/z: 385.0 (M+1).

Provenance & Evidence