Water → HCID 68455996, compound

Participants

Reaction Steps

This title compound by heating a mixture of 3-bromo-8-morpholinopyrido[2,3-d]pyridazine (0.033 g, 0.11 mmol), N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (0.048 g, 0.16 mmol), sodium carbonate (0.049 g, 0.46 mmol) and trans-dichlorobis(triphenyl-phosphine)palladium (II) (0.011 g, 0.016 mmol) in DME (2.1 mL)/H2O (0.9 mL)/EtOH (0.6 mL) at 80° C. The mixture was cooled to RT, evaporated onto silica gel and purified flash chromatography eluting with 2M NH3 in MeOH:CH2Cl2 (0:1→1:19) to give the title compound as a tan amorphous solid. MS m/z: 390.2 [M+1].

Provenance & Evidence