反应详情

温度

140 °C

Ethyl 3-(1-chlorophthalazin-6-yl)-4-methylbenzoate (1.4 g) in acetonitrile (10 mL) was treated with isopropylamine (8 mL, 89 mmol). The mixture was stirred at 140° C. (sealed tube) for 15 h. The mixture was dissolved in 100 mL dichloromethane and was washed with water (20 mL), brine (20 mL), then dried over anhydrous Na2SO4, concentrated in vacuo, and purified by column chromatography eluting with 50% ethyl acetate/DCM to give ethyl 3-(1-(isopropylamino)phthalazin-6-yl)-4-methylbenzoate as a white solid.

1. custom(sealed tube) for 15 h
2. washwas washed with water (20 mL), brine (20 mL)
3. dry with materialdried over anhydrous Na2SO4
4. concentrationconcentrated in vacuo
5. custompurified by column chromatography
6. washeluting with 50% ethyl acetate/DCM