Water → HCID 86607608, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-2-fluoro-3-iodobenzaldehyde oxime (0.860 g, 2.87 mmol) in DMF (5 mL) at RT was added N-chlorosuccinimide (140 mg). The mixture was heated at 55° C. for 5 min. The mixture was allowed to cool below 50° C. and additional N-chlorosuccinimide (282 mg) was added, and heating continued at 55° C. for 20 min. The resulting reaction mixture was allowed to cool to RT and treated with water (20 mL), and extracted with ethyl acetate (3×30 mL). The combined ethyl acetate layers were washed with brine, dried over magnesium sulfate and concentrated to afford 4-chloro-2-fluoro-3-iodobenzoyl chloride oxime as a light yellow amorphous solid. MS (ESI, pos.ion) m/z: 335 (M+1)

Provenance & Evidence