Methylamine → HCID 178485192, compound

Participants

Reaction Steps

Methylamine (33% wt solution in absolute ethanol, 1.9 mL, 18 mmol) was added dropwise to a solution of 4-chloro-2-fluoro-3-iodobenzoyl chloride oxime (0.600 g, 1.8 mmol) in anhydrous THF (10 mL) at 0° C. The reaction mixture was stirred at RT for 1 h. The volatile solvents were removed under reduced pressure. Flash chromatography on silica gel (dichloromethane:hexane 25:75) gave 4-chloro-2-fluoro-N′-hydroxy-3-iodo-N-methylbenzamidine as an amorphous white solid. MS (ESI, pos.ion) m/z: 330.9 (M+1)

Provenance & Evidence