Potassium Carbonate → HCID 68455280, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-bromo-1-chlorophthalazine (Example 1, 0.245 g, 1 mmol), (s,s) tert-butyl 2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylate (0.22 g, 1.1 mmol) and potassium carbonate (0.14 g, 1 mmol) in 5 mL acetonitrile was added to a glass microwave reaction vessel. The reaction mixture was stirred and heated in a Smith Synthesizer® microwave reactor (Personal Chemistry, Inc., Upssala, Sweden) at 180° C. for 20 min. After about 20 min., all starting material was converted to product (M+1=405, 407). The mixture was concentrated under vacuum, and purified via flash chromatography (silica gel) eluting with 1:1 hexane/ethyl acetate to give (0.18 g) tert-butyl 5-(6-bromophthalazin-1-yl)-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylate as a yellow solid. Found MS (ES+): 405, 407(M+H)+.

Provenance & Evidence