Potassium Carbonate → HCID 68454136, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(6-bromophthalazin-1-yl)piperidine-3-carboxamide (0.12g, 0.4 mmol), N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzamide (0.1 g, 0.4 mmol), and tetrakis(triphenylphosphine)palladium (0.02 g, 0.02 mmol) in 5 mL DME/EtOH (4:1) was treated with 2 M potassium carbonate (0.5 mL, 1 mmol). The mixture resulted was warmed up to 90° C. and stirred for 1 h under nitrogen. The mixture was cooled down to room temperature, and the crude product was purified via flash chromatography (silica gel) eluting with a gradient of 4% 2 M ammonia in MeOH/DCM to 6% 2 M ammonia in MeOH/DCM to give (0.11 g) title compound as a pale yellow solid. Found MS (ES+): 430(M+H)+.

Provenance & Evidence