HCID 68453809, compound → HCID 11848246, compound

Participants

Reaction Steps

A mixture of N-cyclopropyl-4-methyl-3-(1-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phthalazin-6-yl)benzamide (20 mg, 50 μmol), 20 mg 10% palladium on activated carbon in 20 mL ethyl acetate was stirred under 50 psi hydrogen at 22° C. After 2 h reaction, the reaction was monitored for product (MS=401) and starting material (MS=399). The reaction mixture was stirred under 50 psi hydrogen at 22° C. for another 2 h, MS showed all starting material was converted to product. The mixture was filtered and washed with methanol 50 mL. After concentrating the filtrate, the residue was purified by PTLC to obtain the title compound (10 mg) as a pale yellow solid. Found MS (ES+): 401 (M+H)+.

Provenance & Evidence