(R)-(-)-2-Amino-1-propanol → HCID 55298733, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (R)-2-aminopropan-1-ol (15 g, 200 mmol) in 200 mL water stirred at 0° C. was added (R)-2-methyloxirane (13 g, 220 mmol) dropwise using a syringe pump over 3 h. The mixture was stirred at 0° C.—RT over 4 h. The mixture was concentrated in vacuo with to remove water. The mixture was vacuum distilled to remove the unreacted alaninol at first (60° C. fraction), then collected the 110-115° C. fraction to give the (R)-2-((R)-2-hydroxypropylamino)propan-1-ol as a sticky pale yellow oil.

Provenance & Evidence