HCID 68452694, compound → HCID 68455662, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-cyclopropyl-4-methyl-3-(1-(4-oxopiperidin-1-yl)phthalazin-6-yl)benzamide (100 mg, 250 μmol) (Method A, followed by deprotection of the ketal) in 5 mL THF was stirred at −78° C. and treated with isopropylmagnesium chloride (250 μl, 499 μmol). The mixture was stirred at −78° C. warming to RT over 4 h. The mixture was quenched with 5 mL sat NH4Cl and extracted with dichloromethane (3×50 mL). The combined organics were dried over anhydrous Na2SO4, concentrated in vacuo and purified by silica gel chromatography eluting with 1-5% 2M ammonia methanol/dichloromethane to give the title compound. Found MS (ES+): 445(M+H)+.

Provenance & Evidence