Hydrochloric Acid → HCID 68453152, compound

Participants

Reaction Steps

(3S)-Tert-butyl 4-(6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)phthalazin-1-yl)-3-methylpiperazine-1-carboxylate (0.2, 0.4 mmol) (Method A) was dissolved in 10 mL MeOH and treated with a 4M solution of HCl (1 mL, 4 mmol) at RT and stirred for 1 h. The mixture was concentrated in vacuo, diluted with 100 mL dichloromethane, washed with sat. NaHCO3, dried over anhydrous Na2SO4 and concentrated in vacuo. The mixture was purified by silica gel chromatography, eluting with 2 M ammonia MeOH/dichloromethane to give the title compound. Found MS (ES+): 402(M+H)+.

Provenance & Evidence