Hydrogen Bromide → HCID 68454065, compound

Participants

Reaction Steps

0.42 g of Tert-butyl 4-(6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)phthalazin-1-yl)piperidine-1-carboxylate was dissolved in 2 mL methanol, treated with 1 mL 48% HBr at RT and stirred for 1 h. The mixture was quenched with 20 mL 10% Na2CO3 and extracted with dichloromethane (3×50 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The crude product was purified by silica gel chromatography, eluting with 10% -20% 2 M ammonia methanol/dichloromethane to give the title product as pale yellow solid. Found MS (ES+): 387(M+H)+.

Provenance & Evidence