Isopropylamine → HCID 86607614, compound

Participants

Reaction Steps

(R)-1-(allyloxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid (0.92 g, 4.3 mmol), 1H-benzo[d][1,2,3]triazol-1-ol (0.70 g, 5.2 mmol), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (1.0 g, 5.2 mmol), and isopropylamine (0.44 mL, 5.2 mmol) were dissolved in dichloromethane (2 mL) and stirred at ambient for 16 h before being diluted with dichloromethane (100 mL), washed 3 times with 50 mL of sodium bicarbonate (saturated, aqueous), separated, dried over sodium sulfate, and concentrated in vacuo. The residue was purified by chromatography to obtain the title compound. MS (ES+): 255 (M+H)+.

Provenance & Evidence