Acetonitrile → HCID 68454221, compound

Participants

Reaction Steps

6-bromo-1-chlorophthalazine (215 mg, 881 μmol), (R)-N-isopropyl-5-methylpyrrolidine-2-carboxamide (150 mg, 881 μmol), and cesium carbonate (1435 mg, 4405 μmol) were added to acetonitrile (4.4 mL) and placed in the microwave for 80 min at 200° C. before being diluted with 75 mL of ethyl acetate, added to a separation funnel, partitioned with sodium bicarbonate (saturated, aqueous), washed 3 times with 50 mL of sodium bicarbonate (saturated, aqueous), separated, dried over sodium sulfate, and concentrated in vacuo to give the crude product. After purification by chromatography, the title compound was obtained. MS (ES+): 377 (M+H)+.

Provenance & Evidence