HCID 68455295, compound → HCID 51357134, compound

Participants

Reaction Steps

(R)-N-Benzyl-2-chloro-N-(1-hydroxypropan-2-yl)acetamide (9.49 g, 39.3 mmol) was dissolved in THF (78.5 mL) before NaH—60% in oil (1.73 g, 43.2 mmol) was added and the mixture stirred at reflux for 4 h. The reaction was quenched with a few drops of water, concentrated, diluted with dichloromethane, filtered, and concentrated to give the title compound. MS (ES+): 206(M+H)+.

Provenance & Evidence