Water → 5-Bromo-2-chloro-4-methoxypyrimidine

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-bromo-2,4-dichloropyrimidine (1.000 mL, 7.82 mmol) in MeOH at 0° C. was added sodium methoxide (1.45 mL, 7.82 mmol). The reaction was warmed up to 23° C. and allowed to stir overnight. Water was added and the mixture was extracted with dichloromethane. The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated to give 1.73 g of 5-bromo-2-chloro-4-methoxypyrimidine as a white solid. ES+=224.9 (M+H)

Provenance & Evidence