Cesium carbonate → 4-Methyl-3-[1-(2-oxo-1-pyrrolidinyl)-6-phthalazinyl]benzamide

Participants

Reaction Steps

In a microwave tube was placed 3-(1-chlorophthalazin-6-yl)-4-methylbenzamide (0.150 g, 0.50 mmol), copper (I) iodide (0.0048 g, 0.025 mmol), (1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine (0.014 g, 0.10 mmol), cesium carbonate (0.34 g, 1.1 mmol) and pyrrolidin-2-one (0.077 mL, 1.0 mmol) in 2 mL of DMF. The mixture was heated at 150°-200° C. for 20 minutes in the microwave. After cooling, the reaction was filtered through Celite®. Water was added to the filtrate and the mixture was extracted with dichloromethane (3×). The organic layer was concentrated and the crude material purified by HPLC to give 4-methyl-3-(1-(2-oxopyrrolidin-1-yl)phthalazin-6-yl)benzamide as white solid. Found MS (ES+)=347 (M+H+)

Provenance & Evidence