Potassium Carbonate → HCID 68453824, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared by a method analogous to that described in Example 11 (Method D), using a mixture of 3-(1-chlorophthalazin-6-yl)-N-cyclopropyl-4-methylbenzamide (0.111 g, 0.33 mmol), 2-cyanophenylboronic acid (0.211 g, 1.4 mmol), potassium carbonate (0.400 g, 2.9 mmol) and trans-dichlorobis(triphenyl-phosphine)palladium (II) (0.017 g, 0.024 mmol) in 1.4 mL DME/0.6 mL H2O/0.4 mL EtOH, which was heated at 120° C. for 15 min. The mixture was partitioned between ethyl acetate/brine and the aqueous layer was extracted with ethyl acetate (3×). The combined organics were evaporated onto silica gel and purified using flash chromatography eluting with 2M NH3 in MeOH:CH2Cl2 (0:1→7:93) to afford the title compound as an amorphous white solid. Found MS m/z: 423 [M+1].

Provenance & Evidence