HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2357676Generated: November 2, 2026
Diethyl Carbonate → (S)-tert-Butyl 3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate
https://huagongshe.com/reaction/2357676
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Carbonate | HCID 7766 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate | HCID 24820294 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-tert-Butyl 3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate | HCID 68455588 | — |
Reaction Steps
A NaOEt solution, prepared from sodium hydride (60% dispersion in mineral oil) (0.990 g, 26 mmol) and 100 mL EtOH, diethyl carbonate (9.00 mL, 74 mmol) and (S)-4-N-BOC-2-hydroxymethyl-piperazine (2.17 g, 10 mmol) was heated at 80° C. The reaction was cooled to RT and filtered. The filtrate was concentrated to dryness to give an off-white amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07759337B2 |
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| Source dataset | uspto-grants-2010_07 |
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| ORD ID | ord-d6086b2cb8124cd29bafaf07cf4d606a |
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| Source note | uspto-grants-2010_07 |
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