Hydrazine → HCID 178518953, compound

HRID 2357680Notes

Reaction equation

HRID 2357680 reaction equation
Cl.[CH2:2]([N:9]1[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=O)[C:11](=O)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:21][NH2:22]>>[CH2:2]([N:9]1[CH2:14][CH2:13][C:12]2[C:15]([OH:17])=[N:21][NH:22][C:11]=2[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 2723880Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

Product 1

HCID 178518953HCID 178518953, compound

Procedure

A mixture of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (10.0 g, 34 mmol, Aldrich) and hydrazine (30 mL, 824 mmol, Aldrich) was stirred at RT for 48 h. The volatile solvents were removed in vacuo, and the residue was azeotroped with MeOH (1×), then recrystallized from MeOH to obtain the title compound MS (ESI, pos. ion) m/z: 230 (M+1).

Workup

  1. customThe volatile solvents were removed in vacuo
  2. customthe residue was azeotroped with MeOH (1×)
  3. customrecrystallized from MeOH

Sources & evidence

ORD record
ord-c9d3f1878d6c4095b468ce2d115b40fb
Source dataset
uspto-grants-2010_07
Patent number
US07759337B2

Reaction notes

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