HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-cyclopropyl-4-methyl-3-(1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)phthalazin-6-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(Dicyclohexylphosphino)-2'-methylbiphenyl | HCID 2734938 | — |
| Reactant | N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide | HCID 21914577 | — |
| Reactant | 6-chloro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)phthalazine | HCID 68453553 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-cyclopropyl-4-methyl-3-(1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)phthalazin-6-yl)benzamide | HCID 68455294 | — |
Reaction Steps
The title compound was prepared according to the method described in Example 8 (Method A) using 6-chloro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)phthalazine (350 mg, 987 μmol), N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (594 mg, 1973 μmol), 2-(dicyclohexylphosphino)-2′-methylbiphenyl (32 mg, 89 μmol), Pd2(dba)3 (27 mg, 30 μmol, Strem), and potassium carbonate (409 mg, 2960 μmol) in dioxane:H2O=4:1 (5 mL). Found MS (ES+) m/z: 494 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759337B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-6ec62f49a772418e93119b749da04e01 |
| Source note | uspto-grants-2010_07 |